Publications

203) N. W. Kreofsky, P. Roy, R. Ghosh, S. Panda, C. Sarisozen, T. M. Reineke "Blending carbohydrate and quinine-based polymers imparts colloidal stability, improved performance, and cell specificity for mRNA delivery," Biomacromolecules 2025, XXXX, XXX, XXX-XXX DOI:

202) N. Rackstraw, T. Weinstein, J. Reineke, J. Kim, B. Reiner, K. Ogawa, L. Leal, P. Dauenhauer, T. M. Reineke "Thiol-ene Reactions Enable Precise Control Over Water-Soluble Cellulosics," ACS Appl. Polym. Mater. 2025, XXXX, XXX, XXX-XXX DOI: https://doi.org/10.1021/acsapm.5c01762

201) C. Zheng, K. Luo, S. Das, P. Chen, Z. Shen, J. Jaye, D. Li, M. Calabrese, T. M. Reineke, M. Mahanthappa, K. Dorfman, T. Lodge, J. Siepmann "Exploring the Self-assembly of Glycolipids into Three-dimensional Network Phases," J. Phys. Chem. B 2025, 129, 32, 8231–8243 DOI: https://doi.org/10.1021/acs.jpcb.5c03135

200) M. M. Abed, C. Wouters, C. Froehlich, T. Nguyen, R. Caldwell, K. Riley, P, Roy, T. M. Reineke, C. Haynes "A Machine Learning-enabled SERS Sensor: Multiplex Detection of Lipopolysaccharides from Foodborne Pathogenic Bacteria," ACS Appl. Mater. Interfaces 2025, 17, 31, 45139–45149 DOI: https://doi.org/10.1021/acsami.5c08361

199) C. J. LaSalle, D. V. Morrissey, T. M. Reineke "Clickable and Degradable Polycarbonate Vehicles for mRNA Delivery," Bioconjugate Chem. 2025, 36, 8, 1628–1638 DOI: https://doi.org/10.1021/acs.bioconjchem.5c00073

198) J. Kim, E. A. Prebihalo, M. K. Porwal, N. B. Rackstraw, T. J. Weinstein, B. Reiner, L. Leal, K. Ogawa, P. J. Dauenhauer, T. M. Reineke "Degradable Thermosets from Cellulose Acetate Allyl Carbonate via Thiol–ene Click Chemistry," Green Chem. 2025 DOI: https://doi.org/10.1039/D5GC00794A

197) S. Panda, E.J. Eaton, P. Muralikrishnan, E.M. Stelljes, D. Seelig, M.C. Leyden, A.K. Gilkey, J.T. Barnes, D.V. Morrissey, S. Sarupria, B.S. Moriarity, T.M. Reineke "Machine Learning Reveals Amine Type in Polymer Micelles Determines mRNA Binding, In Vitro, and In Vivo Performance for Lung-Selective Delivery," JACS Au 2025, 5, 4, 1845–1861. DOI: https://doi.org/10.1021/jacsau.5c00084

196) M.J. Osborn, S. Panda, T.M. Reineke , J. Tolar, A. Nyström "Progress in Skin Gene Therapy: From the Inside and Out," Mol. Ther. 2025, XXX-XXX. DOI: https://doi.org/10.1016/j.ymthe.2025.03.017

195) P. Roy, N.W. Kreofsky, C.F. Santa Chalarca, T.M. Reineke "Binary Copolymer Blending Enhances pDNA Delivery Performance and Colloidal Shelf Stability of Quinine-Based Polyplexes," Bioconjugate Chem. 2025, XXXX, XXX, XXX-XXX. DOI: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.5c00040

194) E.M. Maines, A. Zografos, C.S. Sample, A.J. Zervoudakis, T.M. Reineke, C.J. Ellison "Pendant Hydroxy Polyethylene Reactive Additives for Improved Mechanical Properties and Melt Processability of Poly(ethylene terephthalate)/Polyethylene Blends," Macromolecules 2024, 57, 23, 11042–11054. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.4c01329

193) N.W. Kreofsky, P. Roy, T.M. Reineke "pH-Responsive Micelles Containing Quinine Functionalities Enhance Intracellular Gene Delivery and Expression," Bioconjugate Chem. 2024, 35, 11, 1762–1778. DOI: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00326

192) P. Roy, N.W. Kreofsky, T.M. Reineke "Quinine-Based Polymers are Versatile and Effective Vehicles for Intracellular pDNA, mRNA, and Cas9 Protein Delivery," Biomacromolecules 2024, 25, 10, 6693–6707. DOI: https://pubs.acs.org/doi/10.1021/acs.biomac.4c00925

191) E.A. Prebihalo, T.M. Reineke "Natural Product-Based Pressure-Sensitive Adhesives via Carveol-Dithiothreitol Thiol–Ene Step-Growth Polymerization," ACS Macro Lett. 2024, 13, 10, 1355–1361. DOI: https://pubs.acs.org/doi/10.1021/acsmacrolett.4c00481

190) J.K. Soeherman, J. Kim, T.M. Onn, T. Reineke, P.J. Dauenhauer "Catalytic Hydrogenation of Alkylphenols for Renewable Caprolactone," ACS Sustainable Chem. Eng. 2024, 12, 36, 13598–13608. DOI: https://pubs.acs.org/doi/10.1021/acssuschemeng.4c04610

189) M.C. Leyden, F. Oviedo, S. Saxena, R. Kumar, N. Le, T.M. Reineke "Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery," Bioconjugate Chem. 2024, 35, 7, 897–911. DOI: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00028

188) C.L. Wouters, M.M. Abed, T.B. Nguyen, C.E. Froehlich, P. Roy, T.M. Reineke, C.L. Haynes "Label-Free Detection of Virus-like Particles with Surface-Enhanced Raman Spectroscopy through Analyte Localization and Polymer-Enabled Capture," Anal. Chem. 2024, 96, 25, 10302–10312. DOI: https://pubs.acs.org/doi/10.1021/acs.analchem.4c01117

187) J. Kim, N.B. Rackstraw, T.J. Weinstein, B. Reiner, L. Leal, K. Ogawa, P.J. Dauenhauer, T.M. Reineke "Cellulose Etherification with Glycidol for Aqueous Rheology Modification," ACS Appl. Polym. Mater. 2024, 6, 11, 6714–6725. DOI: https://doi.org/10.1021/acsapm.4c01002

186) R.J. Dalal, F. Oviedo, M.C. Leyden, T.M. Reineke "Polymer Design via SHAP and Bayesian Machine Learning Optimizes pDNA and CRISPR Ribonucleoprotein Delivery," Chem. Sci. 2024, 15, 7219–7228 . DOI: https://doi.org/10.1039/D3SC06920F

185) E.A. Prebihalo, M. Johnson, T.M. Reineke "Bio-Based Thiol–ene Network Thermosets from Isosorbide and Terpenes," ACS Macro Lett. 2024, 13, 5, 586–591. DOI: https://doi.org/10.1021/acsmacrolett.4c00078

184) E.M. Maines, M.A. Polley, G. Haugstad, B. Zhao, T.M. Reineke, C.J. Ellison "Mechanical Recycling of 3D-Printed Thermosets for Reuse in Vat Photopolymerization," ACS Appl. Polym. Mater. 2024, 6, 8, 4625–4633. DOI: https://doi.org/10.1021/acsapm.4c00184

183) K.E. Barr, M.L. Ohnsorg, L. Liberman, L.G. Corcoran, A. Sarode, K. Nagapudi, C.R. Feder, F.S. Bates, T.M. Reineke "Drug–Polymer Nanodroplet Formation and Morphology Drive Solubility Enhancement of GDC-0810," Bioconjugate Chem. 2024, 35, 4, 499–516. DOI: https://doi.org/10.1021/acs.bioconjchem.4c00018

182) J. Koroth, C. Chitwood, R. Kumar, W.-H. Lin, B.T. Reves, T. Boyce, T.M. Reineke, A.M. Ellingson, C.P. Johnson, L.S. Stone, K.C. Chaffin, N.K. Simha, B.M. Ogle, E.W. Bradley "Identification of a Novel, MSC-induced Macrophage Subtype Via Single-cell Sequencing: Implications for Intervertebral Disc Degeneration Therapy," Front. Cell Dev. Biol. 2024, 11, 1286011. DOI: https://doi.org/10.3389/fcell.2023.1286011

181) S. Das, C. Zheng, T.P. Lodge, J.I. Siepmann, M.K. Mahanthappa, M.A. Calabrese, T.M. Reineke "Self-Assembly of Unusually Stable Thermotropic Network Phases by Cellobiose-Based Guerbet Glycolipids," Biomacromolecules 2024, 25, 2, 1291–1302. DOI: https://doi.org/10.1021/acs.biomac.3c01266

180) N.W. Kreofsky, P. Roy, M.E. Brown, U. Perez, R.E. Leighton, R.R. Frontiera, T.M. Reineke "Cinchona Alkaloid Polymers Demonstrate Highly Efficient Gene Delivery Dependent on Stereochemistry, Methoxy Substitution, and Length," Biomacromolecules 2024, 25, 1, 486–501. DOI: https://doi.org/10.1021/acs.biomac.3c01099

179) H.K. Lembke, A. Espinasse, M.G. Hanson, C.J. Grimme, Z. Tan, T.M. Reineke, E.E. Carlson "Cationic Polymers Enable Internalization of Negatively Charged Chemical Probes into Bacteria," ACS Chem. Biol. 2023, 18, 9, 2063–2072. DOI: https://pubs.acs.org/doi/10.1021/acschembio.3c00351

178) P. Roy, N.W. Kreofsky, M.E. Brown, C. Van Bruggen, T.M. Reineke "Enhancing pDNA Delivery with Hydroquinine Polymers by Modulating Structure and Composition," JACS Au 2023, 3, 7, 1876–1889. DOI: https://doi.org/10.1021/jacsau.3c00126

177) M.G. Hanson, C.J. Grimme, N.W. Kreofsky, S. Panda, T.M. Reineke "Blended Block Polycation Micelles Enhance Antisense Oligonucleotide Delivery," Bioconjugate Chem. 2023, 34, 8, 1418–1428. DOI: https://doi.org/10.1021/acs.bioconjchem.3c00186

176) M.K. Porwal, C.J. Ellison, T.M. Reineke "Biobased Copolymers via Cationic Ring-Opening Copolymerization of Levoglucosan Derivatives and ε-Caprolactone," ACS Macro Lett. 2023, 12, 7, 935–942. DOI: https://doi.org/10.1021/acsmacrolett.3c00251

175) C.J. Grimme, M.G. Hanson, T.M. Reineke "Enhanced ASO-Mediated Gene Silencing with Lipophilic pH Responsive Micelles," Bioconjugate Chem. 2023, 34, 7, 1244–1257. DOI: https://doi.org/10.1021/acs.bioconjchem.3c00133

174) E.A. Prebihalo, A.M. Luke, Y. Reddi, C.J. LaSalle, V.M. Shah, C.J. Cramer, T.M. Reineke "Radical Ring-opening Polymerization of Sustainably-derived Thionoisochromanone," Chem. Sci. 2023, 14, 5689–5698. DOI: https://doi.org/10.1039/D2SC06040J

173) M.K. Porwal, M.M. Hausladen, C.J. Ellison, T.M. Reineke "Biobased and Degradable Thiol–ene Networks from Levoglucosan for Sustainable 3D Printing," Green Chem. 2023, 25, 1488–1502. DOI: https://doi.org/10.1039/D2GC04185E

172) E.A. Gormong, D.S. Sneddon, T.M. Reineke, T.R. Hoye "Neighboring Group Effects on the Rates of Cleavage of Si–O–Si-Containing Compounds," J. Org. Chem. 2023, 88, 4, 1988–1995. DOI: https://doi.org/10.1021/acs.joc.2c02126

171) G.J.L. Bernardes, P. Zou, Z. Dai, E. Lavik, J. van Hest, G. Zheng, N. Quinn, C.M. MacLaughlin, T.M. Reineke "Introducing the 2023 Bioconjugate Chemistry Editorial Team," Bioconjugate Chem. 2023, 34, 2, 279–282. DOI: https://doi.org/10.1021/acs.bioconjchem.3c00033

170) T.M. Reineke "Bioconjugate Chemistry: Enabling Innovation and Fostering Community at the Nexus of Synthetic and Biological Research," Bioconjugate Chem. 2023, 34, 1, 1–2. DOI: https://doi.org/10.1021/acs.bioconjchem.2c00591

169) R.J. Dalal, M.L. Ohnsorg, S. Panda, T.M. Reineke "Hydrophilic Surface-Modification of Cationic Unimolecular Bottlebrush Vectors Moderate pDNA and RNP Bottleplex Stability and Delivery Efficacy," Biomacromolecules 2022, 23, 12, 5179–5192. DOI: https://doi.org/10.1021/acs.biomac.2c00999

168) M.G. Hanson, C.J. Grimme, C.F. Santa Chalarca, T.M. Reineke "Cationic Micelles Outperform Linear Polymers for Delivery of Antisense Oligonucleotides in Serum: An Exploration of Polymer Architecture, Cationic Moieties, and Cell Addition Order," Bioconjugate Chem. 2022, 33, 11, 2121–2131. DOI: https://doi.org/10.1021/acs.bioconjchem.2c00379

167) C.J. Grimme, M.G. Hanson, L.G. Corcoran, T.M. Reineke "Polycation Architecture Affects Complexation and Delivery of Short Antisense Oligonucleotides: Micelleplexes Outperform Polyplexes," Biomacromolecules 2022, 23, 8, 3257–3271. DOI: https://doi.org/10.1021/acs.biomac.2c00338

166) C.F. Santa Chalarca, R.J. Dalal, A. Chapa, M.G. Hanson, and T.M. Reineke "Cation Bulk and pKa Modulate Diblock Polymer Micelle Binding to pDNA," ACS Macro Lett. 2022, 11, 4, 588–594. DOI: https://doi.org/10.1021/acsmacrolett.2c00015

165) M.K. Porwal, Y. Reddi, D.J. Saxon, C.J. Cramer, C.J. Ellison, T.M. Reineke "Stereoregular Functionalized Polysaccharides via Cationic Ring-Opening Polymerization of Biomass-derived Levoglucosan," Chem. Sci. 2022, 13, 4512–4522. DOI: https://doi.org/10.1039/D2SC00146B

164) R. Kumar, N. Le, F. Oviedo, M.E. Brown, T.M. Reineke "Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery," JACS Au 2022, 2, 2, 428–442. DOI: https://doi.org/10.1021/jacsau.1c00467

163) F.M. Haque, J.S.A. Ishibashi, C.A.L. Lidston, H. Shao, F.S. Bates, A.B. Chang, G.W. Coates, C.J. Cramer, P.J. Dauenhauer, W.R. Dichtel, C.J. Ellison, E.A. Gormong, L.S. Hamachi, T.R. Hoye, M. Jin, J.A. Kalow, H.J. Kim, G. Kumar, C.J. LaSalle, S. Liffland, B.M. Lipinski, Y. Pang, R. Parveen, X. Peng, Y. Popowski, E.A. Prebihalo, Y. Reddi, T.M. Reineke, D.T. Sheppard, J.L. Swartz, W.B. Tolman, B. Vlaisavljevich, J. Wissinger, S. Xu, M.A. Hillmyer "Defining the Macromolecules of Tomorrow Through Synergistic Sustainable Polymer Research," Chem. Rev. 2022, 122, 6, 6322–6373. DOI: https://doi.org/10.1021/acs.chemrev.1c00173

162) H. Sajjad, E.A. Prebihalo, W.B. Tolman, T.M. Reineke "Ring Opening Polymerization of β-acetoxy-δ-methylvalerolactone, a Triacetic Acid Lactone Derivative," Polym. Chem. 2021, 12, 6724–6730. DOI: https://doi.org/10.1039/D1PY00561H

161) E. M. Maines, M. K. Porwal, C. J. Ellison, T. M. Reineke "Sustainable Advances in SLA/DLP 3D Printing Materials and Processes," Green Chem. 2021, 23, 6863–6897. DOI: https://doi.org/10.1039/D1GC01489G

160) C. A. DeRosa, A. M. Luke, K. Anderson, T. M. Reineke, W. B. Tolman, F. S. Bates, M. A. Hillmyer "Regioregular Polymers from Biobased (R)-1,3-Butylene Carbonate," Macromolecules 2021, 54, 13, 5974–5984. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.1c00828

159) E. A. Gormong, T. M. Reineke, T. R. Hoye "Synthesis of Isohexide Diyne Polymers and Hydrogenation to Their Saturated Polyethers," ACS Macro Lett. 2021, 10, 8, 1068–1072. DOI: https://pubs.acs.org/doi/10.1021/acsmacrolett.1c00422

158) R. J. Dalal, R. Kumar, M. Ohnsorg, M. Brown, T. M. Reineke "Cationic Bottlebrush Polymers Outperform Linear Polycation Analogues for pDNA Delivery and Gene Expression," ACS Macro Lett. 2021, 10, 7, 886–893. DOI: https://pubs.acs.org/doi/10.1021/acsmacrolett.1c00335

157) M. R. Bockman, R. J. Dalal, R. Kumar, T. M. Reineke "Facile Synthesis of GalNAc Monomers and Block Polycations for Hepatocyte Gene Delivery," Polym. Chem. 2021, 12, 4063–4071. DOI: https://doi.org/10.1039/D1PY00250C

156) C. M. Lau, S. Kim, L. M. Lillie, W. B. Tolman, T. M. Reineke, C. J. Ellison "Structural Basis for the Different Mechanical Behaviors of Two Chemically Analogous, Carbohydrate-Derived Thermosets," ACS Macro Lett. 2021, 10, 5, 609–615. DOI: https://doi.org/10.1021/acsmacrolett.1c00041

155) R. Kumar, C. F. Santa Chalarca, M. R. Bockman, C. V. Bruggen, C. J. Grimme, R. J. Dalal, M. G. Hanson, J. K. Hexum, T. M. Reineke "Polymeric Delivery of Therapeutic Nucleic Acids," Chem. Rev. 2021, 121, 18, 11527–11652. DOI: https://doi.org/10.1021/acs.chemrev.0c00997

154) M. L. Ohnsorg, P. C. Prendergast, L. L. Robinson, M. R. Bockman, F. S. Bates, T. M. Reineke "Bottlebrush Polymer Excipients Enhance Drug Solubility: Influence of End-Group Hydrophilicity and Thermoresponsiveness," ACS Macro Lett. 2021, 10, 3, 375–381. DOI: https://pubs.acs.org/doi/full/10.1021/acsmacrolett.0c00890

153) E. A. Gormong, M. T. Wentzel, B. Cao, L. N. Kundel, T. M. Reineke, J. E. Wissinger "Exploring Divergent Green Reaction Media for the Copolymerization of Bio-based Monomers in the Teaching Laboratory," J. Chem. Educ. 2021, 98, 2, 559–566. DOI: https://pubs.acs.org/doi/10.1021/acs.jchemed.0c00688

152) D. J. Saxon, E. A. Gormong, V. M. Shah, T. M. Reineke "Rapid Synthesis of Chemically Recyclable Polycarbonates From Renewable Feedstocks," ACS Macro Lett. 2021, 10, 1, 98–103. DOI: https://pubs.acs.org/doi/10.1021/acsmacrolett.0c00747

151) H. Sajjad, L. M. Lillie, C. M. Lau, C. J. Ellison, W. B. Tolman, T. M. Reineke "Degradable Polyanhydride Networks Derived from Itaconic Acid," Polym. Chem. 2021, 12, 608–617. DOI: https://pubs.rsc.org/en/content/articlelanding/2021/py/d0py01388a/unauth#!divAbstract

150) R. Kumar, N. Le, Z. Tan, M. E. Brown, S. Jiang, T. M. Reineke "Efficient Polymer-Mediated Delivery of Gene Editing Ribonucleoprotein Payloads through Combinatorial Design, Parallelized Experimentation, and Machine Learning," ACS Nano 2020, 14, 12, 17626–17639. DOI: https://pubs.acs.org/doi/abs/10.1021/acsnano.0c08549

149) C. Van Bruggen, D. Punihaole, A. R. Keith, A. J. Schmitz, J. Tolar, R. R. Frontiera, T. M. Reineke "Quinine Copolymer Reporters Promote Efficient Intracellular DNA Delivery and Illuminate Protein-Induced Unpackaging Mechanism," Proc. Nat. Acad. Sci. USA 2020, 117, 52, 32919–32928. DOI: https://www.pnas.org/content/early/2020/12/09/2016860117

148) R. S. Rodriguez, V. M. Szlag, T. M. Reineke, C. L. Haynes "Multiplex Surface-enhanced Raman Scattering Detection of Deoxynivalenol and Ochratoxin A with a Linear Polymer Affinity Agent," Mater. Adv. 2020, 1, 3256–3266. DOI: https://pubs.rsc.org/en/content/articlelanding/2020/MA/D0MA00608D#!divAbstract

147) M. J. Styles, R. S. Rodriguez, V. M. Szlag, S. Bryson, Z. Gao, S. Jung, T. M. Reineke, C. L. Haynes "Optimization of Film over Nanosphere Substrate Fabrication for SERS Sensing of the Allergen Soybean Agglutinin," J. Raman Spectrosc. 2020, 1–9. DOI: https://onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6019?af=R

146) M. G. Hanson, J. S. Katz, H. Ma, M. Putterman, B. A. Yezer, O. Petermann, T. M. Reineke "Effects of Hydrophobic Tail Length Variation on Surfactant-Mediated Protein Stabilization," Acc. Chem. Res. 2020, 17, 4302–4311. DOI: https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00737

145) S. P. Ertem, C. E. Onuoha, H. Wang, M. A. Hillmyer, T. M. Reineke, T. P. Lodge, F. S. Bates "Hydrogenolysis of Linear Low-density Polyethylene During Heterogeneous Catalytic Hydrogen-Deuterium Exchange," Macromolecules 2020, 53, 6043–6055. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.0c00696

144) H. Sajjad, W. B. Tolman, T. M. Reineke "Block Copolymer Pressure Sensitive Adhesives Derived From Fatty Acids and Triacetic Acid Lactone," ACS Appl. Polym. Mater. 2020, 2, 2719–2728. DOI: https://pubs.acs.org/doi/10.1021/acsapm.0c00317

143) Z. Shen, J. L. Chen, V. Vernadskaia, S. P. Ertem, M. K. Mahanthappa, M. A. Hillmyer, T. M. Reineke, T. P. Lodge, J. I. Siepmann "From Order to Disorder: Computational Design of Triblock Amphiphiles with 1 nm Domains," J. Am. Chem. Soc. 2020, 142, 9352–9362. DOI: https://pubs.acs.org/doi/10.1021/jacs.0c01829

142) N. P. Ingle, J. K. Hexum, T. M. Reineke "Polyplexes Are Endocytosed By and Trafficked Within Filopodia," Biomacromolecules 2020, 21, 1379–1392. DOI: https://pubs.acs.org/doi/10.1021/acs.biomac.9b01610

141) A. M. Luke, A. Peterson, S. Chiniforoush, M. Mandal, Y. Popowski, H. Sajjad, C. J. Bouchey, D. Y. Shopov, B. J. Graziano, L. J. Yao, C. J. Cramer, T. M. Reineke, W. B. Tolman "Mechanism of Initiation Stereocontrol in Polymerization of rac-Lactide by Aluminum Complexes Supported by Indolide-Imine Ligands," Macromolecules 2020, 53, 1809–1818. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.0c00092

140) P. W. Schmidt, S. Morozova, S. P. Ertem, M. L. Coughlin, I. Davidovich, Y. Talmon, T. M. Reineke, F. S. Bates, T. P. Lodge "Internal Structure of Methylcellulose Fibrils," Macromolecules 2020, 53, 398–405. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.9b01773

139) D. J. Saxon, A. M. Luke, H. Sajjad, W. B. Tolman, T. M. Reineke "Next-generation Polymers: Isosorbide as a Renewable Alternative," Prog. Polym. Sci. 2020, 101, 101196. DOI: https://www.sciencedirect.com/science/article/pii/S0079670019302023

138) S.-S. Kim, C. M. Lau, L. M. Lillie, W. B. Tolman, T. M. Reineke, C. J. Ellison "Degradable Thermoset Fibers from Carbohydrate-Derived Diols via Thiol-ene Photopolymerization," ACS Appl. Polym. Mater. 2019, 1, 2933–2942. [ACS Editors' Choice]. DOI: https://pubs.acs.org/doi/10.1021/acsapm.9b00647

137) Z. Tan, Y. Jiang, M. S. Ganewatta, R. Kumar, A. Keith, K. Twaroski, T. Pengo, J. Tolar, T. P. Lodge, T. M. Reineke "Block Polymer Micelles Enable CRISPR/Cas9 Ribonucleoprotein Delivery: Physico-Chemical Properties Affect Packaging Mechanisms and Gene Editing Efficiency," Macromolecules 2019, 52, 8197–8206. DOI: https://pubs.acs.org/doi/abs/10.1021/acs.macromol.9b01645

136) S. Morozova, M. L. Coughlin, J. T. Early, S. P. Ertem, T. M. Reineke, F. S. Bates, T. P. Lodge "Properties of Chemically Cross-linked Methylcellulose Gels," Macromolecules 2019, 52, 7740–7748. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.9b01401

135) A. A. Purchel, W. S. Boyle, T. M. Reineke "Aggregated Solution Morphology of Poly(acrylic acid)-Poly(styrene) Block Copolymers Improves Drug Supersaturation Maintenance and Caco-2 Cell Membrane Permeation," Acc. Chem. Res. 2019, 16, 4423–4435. DOI: https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.9b00002

134) Z. Tan, Y. Jiang, W. Zhang, L. Karls, T. P. Lodge, T. M. Reineke "Polycation Architecture and Assembly Direct Successful Gene Delivery: Micelleplexes Outperform Polyplexes via Optimal DNA Packaging," J. Am. Chem. Soc. 2019, 141, 15804–15817. DOI: https://pubs.acs.org/doi/10.1021/jacs.9b06218

133) V. M. Szlag, R. S. Rodriguez, S. Jung, M. R. Bourgeois, S. Bryson, A. Purchel, G. C. Schatz, C. L. Haynes, T. M. Reineke "Optimizing Linear Polymer Affinity Agent Properties for Surface-enhanced Raman Scattering Detection of Aflatoxin B1," Mol. Syst. Des. Eng. 2019, 4, 1019–1031. DOI: https://pubs.rsc.org/en/content/articlelanding/2019/ME/C9ME00032A#!divAbstract

132) L. Xiao, C. Ching, Y. Ling, M. Nasiri, M. J. Klemes, T. M. Reineke, D. E. Helbling, W. R. Dichtel "Crosslinker Chemistry Determines the Uptake Potential of Perfluorinated Alkyl Substances by β-Cyclodextrin Polymers," Macromolecules 2019, 52, 3747–3752. DOI: https://pubs.acs.org/doi/10.1021/acs.macromol.9b00417

131) M. L. Ohnsorg, J. M. Ting, S. D. Jones, S. Jung, F. S. Bates, T. M. Reineke "Tuning PNIPAm Self-Assembly and Thermoresponse: Roles of Hydrophobic End-Groups and Hydrophilic Comonomer," Polym. Chem. 2019, 10, 3469–3479. DOI: https://pubs.rsc.org/en/content/articlelanding/2019/py/c9py00180h#!divAbstract

130) C. Van Bruggen, J. K. Hexum, Z. Tan, R. J. Dalal, T. M. Reineke "Nonviral Gene Delivery with Cationic Glycopolymers," Acc. Chem. Res. 2019, 52, 1347–1358. [ACS Editors' Choice]. DOI: https://pubs.acs.org/doi/10.1021/acs.accounts.8b00665

129) H. R. Phillips, Z. P. Tolstyka, B. C. Hall, J. K. Hexum, P. B. Hackett, T. M. Reineke "Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and In Vivo Biodistribution," Biomacromolecules 2019, 20, 1530–1544. DOI: https://pubs.acs.org/doi/full/10.1021/acs.biomac.8b01704

128) D. J. Saxon, M. Nasiri, M. Mandal, S. Maduskar, P. J. Dauenhauer, C. J. Cramer, A. M. LaPointe, T. M. Reineke "Architectural Control of Isosorbide-based Polyethers via Ring-opening Polymerization," J. Am. Chem. Soc. 2019, 141, 5107–5111. DOI: https://pubs.acs.org/doi/10.1021/jacs.9b00083

127) T. M. Reineke, R. T. Raines, V. M. Rotello "Delivery of Proteins and Nucleic Acids: Achievements and Challenges," Bioconjugate Chem. 2019, 30, 261–262. DOI: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00096

126) R. Ding, Y. Du, R. Goncalves, L. Francis, T. M. Reineke "Sustainable Near UV-curable Acrylates Based on Natural Phenolics for Stereolithography 3D Printing," Polym. Chem. 2019, 10, 1067-1077. DOI: https://pubs.rsc.org/en/content/articlelanding/2019/py/c8py01652f#!divAbstract

125) W. S. Boyle, W. Chen, A. Rodriguez, S. Linn, J. Tolar, K. Lozano, T. M. Reineke "Ternary composite nanofibers containing chondroitin sulfate scavenge inflammatory chemokines from solution and prohibit squamous cell carcinoma migration," ACS Appl. Bio Mater. 2019, 2, 619–624. DOI: https://pubs.acs.org/doi/10.1021/acsabm.8b00690

124) V. Maliekkal, S. Maduskar, D. Saxon, M. Nasiri, T. M. Reineke, M. Neurock, P. J. Dauenhauer "Activation of Cellulose via Cooperative Hydroxyl-Catalyzed Transglycosylation of Glycosidic Bonds," ACS Catal. 2019, 9, 1943–1955. DOI: https://pubs.acs.org/doi/10.1021/acscatal.8b04289

123) M. Mandal, A. M. Luke, B. Dereli, C. E. Elwell, T. M. Reineke, W. B. Tolman, C. J. Cramer "Computational Prediction and Experimental Verification of ε-Caprolactone Ring-Opening Polymerization Activity by an Aluminum Complex of an Indolide/Schiff-base Ligand," ACS Catal. 2019, 9, 885–889. DOI: https://pubs.acs.org/doi/10.1021/acscatal.8b04540

122) W. Boyle, K. Twaroski, E. Woska, J. Tolar, T. M. Reineke "Molecular additives significantly enhance glycopolymer-mediated transfection of large plasmids and functional CRISPR-Cas9 transcription activation ex vivo in primary human fibroblasts and induced pluripotent stem cells," Bioconjugate Chem. 2019, 30, 418–431. DOI: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00760

121) S. N. Crooke, J. Zheng, M. S. Ganewatta, S. M. Guldberg, T. M. Reineke, M. G. Finn "Immunological properties of protein-polymer nanoparticles," ACS Appl. Bio Mater. 2019, 2, 93–103. DOI: https://pubs.acs.org/doi/10.1021/acsabm.8b00418

120) V. M. Szlag, S. Jung, R. S. Rodriguez, M. Bourgeois, S. Bryson, G. Schatz, T. M. Reineke, C. L. Haynes "Isothermal Titration Calorimetry for the Screening of Aflatoxin B1 Surface-enhanced Raman Scattering Sensor Affinity Agents," Anal. Chem. 2018, 90, 13409–13418. DOI: https://pubs.acs.org/doi/10.1021/acs.analchem.8b03221

119) D. Punihaole, R. J. Workman, S. Upadhyay, C. Van Bruggen, A. J. Schmitz, T. M. Reineke, R. R. Frontiera "New Insights into Quinine-DNA Binding Using Raman Spectroscopy and Molecular Dynamics Simulations," J. Phys. Chem. B 2018, 122, 9840–9851. DOI: https://pubs.acs.org/doi/10.1021/acs.jpcb.8b05795

118) Q. Zhang, H. R. Phillips, A. Purchel, J. K. Hexum, T. M. Reineke "Sustainable and Degradable Epoxy Resins from Trehalose, Cyclodextrin, and Soybean Oil Yield Tunable Mechanical Performance and Cell Adhesion," ACS Sustainable Chem. Eng. 2018, 6, 14967–14978. DOI: https://pubs.acs.org/doi/10.1021/acssuschemeng.8b03460

117) V. Szlag, R. Rodriguez, J. He, N. Hudson-Smith, H. Kang, N. Le, T. M. Reineke, C. L. Haynes "Molecular Affinity Agents for Intrinsic Surface-enhanced Raman Scattering (SERS) Sensors," ACS Appl. Mater. Interfaces 2018, 10, 31825–31844. DOI: https://pubs.acs.org/doi/10.1021/acsami.8b10303

116) Y. Jiang, T. P. Lodge, T. M. Reineke "Packaging pDNA by Polymeric ABC Micelles Simultaneously Achieves Colloidal Stability and Structural Control," J. Am. Chem. Soc. 2018, 140, 11101–11111. DOI: https://pubs.acs.org/doi/full/10.1021/jacs.8b06309

115) D. S. Park, O. A. Abdelrahman, K. P. Vinter, P. M. Howe, J. Q. Bond, T. M. Reineke, K. Zhang, P. J. Dauenhauer "Multifunctional Cascade Catalysis of Itaconic Acid Hydrodeoxygenation to 3-Methyl-Tetrahydrofuran," ACS Sustainable Chem. Eng. 2018, 6, 9394–9402. DOI: https://pubs.acs.org/doi/10.1021/acssuschemeng.8b01743

114) L. M. Lillie, W. B. Tolman, T. M. Reineke "Degradable and Renewably-sourced Poly(ester-thioethers) by Photo-initiated Thiol-ene Polymerization," Polym. Chem. 2018, 9, 3272–3278. DOI: http://pubs.rsc.org/en/content/articlelanding/2018/py/c8py00502h#!divAbstract

113) D. Schneiderman, J. Ting, A. Purchel, R. Miranda, M. Tirrell, T. M. Reineke, S. Rowan "Open-to-Air RAFT Polymerization in Complex Solvents: From Whisky to Fermentation Broth," ACS Macro Lett. 2018, 7, 406–411. DOI: https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00069

112) M. Nasiri, D. Saxon, T. M. Reineke "Enhanced Mechanical and Adhesion Properties in Sustainable Triblock Copolymers via Non-covalent Interactions," Macromolecules 2018, 51, 2456–2465. DOI: https://pubs.acs.org/doi/abs/10.1021/acs.macromol.7b02248

111) M. S. Ganewatta, Md A. Rahman, L. Mercado, T. Shokfai, A. W. Decho, T. M. Reineke, C. Tang "Facially Amphiphilic Polyionene Biocidal Polymers Derived from Lithocholic Acid," Bioact. Mater. 2018, 3, 186–193. DOI: https://www.sciencedirect.com/science/article/pii/S2452199X17301214

110) Y. Jiang, T. M. Reineke, T. P. Lodge "Complexation of DNA with Cationic Copolymer Micelles: Effects of DNA Length and Topology," Macromolecules 2018, 51, 1150–1160. DOI: https://pubs.acs.org/doi/abs/10.1021/acs.macromol.7b02201

109) S. Jung, T. P. Lodge, T. M. Reineke "Structures and Protonation States of Hydrophilic-Cationic Diblock Copolymers and Their Binding with Plasmid DNA," J. Phys. Chem. B 2018, 122, 2449–2461. DOI: https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.7b07902

108) J. M. Ting, W. Porter, J. Mecca, F. S. Bates, T. M. Reineke "Advances in Polymer Design for Enhancing Oral Drug Solubility and Delivery," Bioconjugate Chem. 2018, 29, 939–952. DOI: http://pubs.acs.org/doi/10.1021/acs.bioconjchem.7b00646

107) Z. Tan, Y. Dhande, T. M. Reineke "Cell penetrating polymers containing guanidinium trigger apoptosis in human hepatocellular carcinoma cells unless conjugated to a targeting N-acetyl galactosamine block," Bioconjugate Chem. 2017, 28, 2985–2997. DOI: http://pubs.acs.org/doi/full/10.1021/acs.bioconjchem.7b00598

106) N. A. Wilkinson, A. E. Metaxas, C. Quinney, S. Wickramaratne, T. M. Reineke, C. S. Dutcher "pH Dependence of Bentonite Aggregate Size and Morphology on Polymer-Clay Flocculation," Colloids Surf. A 2017, 537, 281–286. DOI: http://www.sciencedirect.com/science/article/pii/S0927775717308993

105) S. Tale, A. Purchel, M. Dalsin, T. M. Reineke "Diblock terpolymers are tunable and pH responsive vehicles to increase hydrophobic drug solubility for oral administration," Mol. Pharmaceutics 2017, 14, 4121–4127. DOI: http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.7b00458

104) Y. Wu, A. E. Smith, T. M. Reineke "Lipophilic Polycation Vehicles Display High Plasmid DNA Delivery to Multiple Cell Types," Bioconjugate Chem. 2017, 28, 2035–2040. DOI: http://pubs.acs.org/doi/full/10.1021/acs.bioconjchem.7b00306

103) N. Wilkinson, A. Metaxas, E. Brichetto, S. Wickramaratne, T. M. Reineke, C. S. Dutcher "Ionic Strength Dependence of Aggregate Size and Morphology on Polymer-Clay Flocculation," Colloids Surf. A 2017, 529, 1037–1046. DOI: http://www.sciencedirect.com/science/article/pii/S0927775717306477

102) Y. Jiang, D. Sprouse, J. Laaser, Y. Dhande, T. M. Reineke, T. P. Lodge "Complexation of Linear DNA and Polystyrene Sulfonate with Cationic Copolymer Micelles: Effect of Polyanion Flexibility," J. Phys. Chem. B 2017, 121, 6708–6720. DOI: http://pubs.acs.org/doi/full/10.1021/acs.jpcb.7b03732

101) L. M. Lillie, W. B. Tolman, T. M. Reineke "Structure/Property Relationships in Copolymers Comprising Renewable Isosorbide, Glucarodilactone, and 2,5-Bis(hydroxymethyl)furan Subunits," Polym. Chem. 2017, 8, 3746–3754. DOI: http://pubs.rsc.org/en/content/articlelanding/2017/py/c7py00575j#!divAbstract

100) J. M. Ting, R. G. Ricarte, D. K. Schneiderman, S. A. Saba, Y. Jiang, M. A. Hillmyer, F. S. Bates, T. M. Reineke, C. W. Macosko, T. P. Lodge "Polymer Day: Outreach Experiments for High School Students," J. Chem. Educ. 2017, 94, 1629–1638. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.jchemed.6b00767

99) J. E. Laaser, M. McGovern, Y. Jiang, E. Lohmann, T. M. Reineke, D. Morse, K. Dorfman, T. P. Lodge "Equilibration of Micelle−Polyelectrolyte Complexes: Mechanistic Differences between Static and Annealed Charge Distributions," J. Phys. Chem. B 2017, 121, 4631–4641. DOI: http://pubs.acs.org/doi/full/10.1021/acs.jpcb.7b01953

98) R. Ricarte, Z. Li, L. Johnson, J. Ting, T. M. Reineke, F. S. Bates, M. A. Hillmyer, T. P. Lodge "Direct Observation of Nanostructures During Aqueous Dissolution of Polymer/Drug Particles," Macromolecules 2017, 50, 3143–3152. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.macromol.7b00372

97) S. Jung, T. P. Lodge, T. M. Reineke "Complexation Between DNA and Hydrophilic-Cationic Diblock Copolymers," J. Phys. Chem. B 2017, 121, 2230–2243. DOI: http://pubs.acs.org/doi/full/10.1021/acs.jpcb.6b11408

96) J. Zheng, S. Jung, P. Schmidt, T. P. Lodge, T. M. Reineke "2-Hydroxyethylcellulose and Amphiphilic Block Polymer Conjugates Form Mechanically Tunable and Nonswellable Hydrogels," ACS Macro Lett. 2017, 6, 145–149. DOI: http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.6b00954

95) W. Boyle, K. Senger, J. Tolar, T. M. Reineke "Heparin Enhances Transfection in Concert with Trehalose-Based Polycations with Challenging Cell Types," Biomacromolecules 2017, 18, 56–67. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b01297

94) Q. Zhang, M. Molenda, T. M. Reineke "Epoxy resin thermosets derived from trehalose and β-cyclodextrin," Macromolecules 2016, 49, 8397–8406. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.macromol.6b01861

93) J. Ting, S. Tale, A. Purchel, S. Jones, L. Widanapathirana, Z. Tolstyka, L. Guo, S. Guillaudeu, F. S. Bates, T. M. Reineke "High–throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals," ACS Cent. Sci. 2016, 2, 748–755. DOI: http://pubs.acs.org/doi/full/10.1021/acscentsci.6b00268

92) J. Laaser, E. Lohmann, Y. Jiang, T. M. Reineke, T. P. Lodge "Architecture-Dependent Stabilization of Polyelectrolyte Complexes Between Polyanions and Cationic Triblock Terpolymer Micelles," Macromolecules 2016, 49, 6644–6654. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.macromol.6b01408

91) D. Sprouse, Y. Jiang, J. Laaser, T. P. Lodge, T. M. Reineke "Tuning Cationic Block Copolymer Micelle Size by pH and Ionic Strength," Biomacromolecules 2016, 17, 2849–2859. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00654

90) M. Nasiri, T. M. Reineke "Sustainable glucose-based block copolymers exhibit elastomeric and adhesive behavior," Polym. Chem. 2016, 7, 5233–5240. DOI: http://pubs.rsc.org/en/content/articlelanding/2016/py/c6py00700g#!divAbstract

89) V. M. Szlag, M. J. Styles, L. R. Madison, A. R. Campos, B. S. Wagh, D. Sprouse, G. C. Schatz, T. M. Reineke, C. L. Haynes "SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers," ACS Sens. 2016, 1, 842–846. DOI: http://pubs.acs.org/doi/abs/10.1021/acssensors.6b00209

88) J. J. Gallagher, M. A. Hillmyer, T. M. Reineke "Acrylic triblock copolymers incorporating isosorbide for pressure sensitive adhesives," ACS Sustainable Chem. Eng. 2016, 4, 3379–3387. DOI: http://pubs.acs.org/doi/abs/10.1021/acssuschemeng.6b00455

87) P. Agrawal, N. P. Ingle, W. Boyle, E. Ward, J. Tolar, K. Dorfman, T. M. Reineke "Fast, efficient and gentle transfection of human adherent cells in suspension," ACS Appl. Mater. Interfaces 2016, 8, 8870–8874. DOI: http://pubs.acs.org/doi/abs/10.1021/acsami.6b01702

86) K. Hurley, H. Ring, M. Etheridge, J. Zhang, Z. Gao, Q. Shao, N. Klein, V. Szlag, C. Chung, T. M. Reineke, M. Garwood, J. Bischof, C. Haynes "Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle," Mol. Pharmaceutics 2016, 13, 2172–2183. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00866

85) N. Wilkinson, A. Metaxas, E. Ruud, E. Raethke, S. Wickramaratne, T. M. Reineke, C. S. Dutcher "Internal Structure Visualization of Polymer–Clay Flocculants Using Fluorescence," Colloid Interface Sci. Commun. 2016, 10-11, 1-5. DOI: http://www.sciencedirect.com/science/article/pii/S2215038215300662

84) Y. Dhande, B. Wagh, B. Hall, D. Sprouse, P. Hackett, T. M. Reineke "N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery," Biomacromolecules 2016, 17, 830–840. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b01555

83) T. M. Reineke "Stimuli Responsive Polymers For Biological Detection and Delivery," ACS Macro Lett. 2016, 5, 14-18. DOI: http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00862

82) D. Sprouse, T. M. Reineke, M. E. Davis "Polymeric Delivery Vehicles for Exogenous Nucleic Acid Delivery," Reference Module in Materials Science and Materials Engineering 2016, Elsevier, ISBN: 9780128035818. DOI: http://www.sciencedirect.com/science/article/pii/B9780128035818015162

81) Z. Tolstyka, H. R. Phillips, M. Cortez, Y. Wu, N. P. Ingle, J. Bell, P. Hackett, T. M. Reineke "Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and In Vivo pDNA Delivery," ACS Biomat. Sci. Eng. 2016, 2, 43–55. DOI: http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00312

80) J. Laaser, Y. Jiang, S. Petersen, T. M. Reineke, T. P. Lodge "Interpolyelectrolyte Complexes of Polycationic Micelles and Linear Polyanions: Structural Stability and Temporal Evolution," J. Phys. Chem. B 2015, 119, 15919–15928. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.jpcb.5b09010

79) J. M. Ting, T. S. Navale, S. D. Jones, F. S. Bates, T. M. Reineke "Deconstructing HPMCAS: Excipient Design to Tailor Polymer-drug Interactions for Oral Administration," ACS Biomat. Sci. Eng. 2015, 1, 978-990. DOI: http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00234

78) L. Xue, S. S. Kelkar, X. Wang, J. Ma, L. A. Madsen, T. M. Reineke "A theranostic polycation containing trehalose and lanthanide chelate domains for siRNA delivery and monitoring," RSC Adv. 2015, 5, 74102-74106. DOI: http://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra14325j#!divAbstract

77) L. Widanapathirana, S. Tale, T. M. Reineke "Dissolution and solubility enhancement of the highly lipophilic drug phenytoin via interaction with poly(N-isopropylacrylamide-co-vinylpyrrolidone) excipients," Mol. Pharmaceutics 2015, 12, 2537–2543. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00202

76) J. Laaser, Y. Jiang, D. Sprouse, T. M. Reineke, T. P. Lodge "pH- and Ionic Strength-Induced Contraction of Polybasic Micelles in Buffered Aqueous Solutions," Macromolecules 2015, 48, 2677–2685. DOI: http://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b00360

75) J. J. Gallagher, M. A. Hillmyer, T. M. Reineke "Isosorbide-based Polymethacrylates," ACS Sustainable Chem. Eng. 2015, 3, 662–667. DOI: http://pubs.acs.org/doi/abs/10.1021/sc5008362

74) W. Shearouse, L. Lillie, T. M. Reineke, W. Tolman "Sustainable Polyesters Derived from Glucose and Castor Oil: Building Block Structure Impacts Properties," ACS Macro Lett. 2015, 4, 284–288. DOI: http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00099

73) X. Wang, Y. Chen, L. Xue, N. Pothyaee, R. Zhang, J. Riffle, T. M. Reineke, L. A. Madsen "Diffusion of Drug Delivery Nanoparticles into Biogels using Time-Resolved MicroMRI," J. Phys. Chem. Lett. 2014, 5, 3825–3830. DOI: http://pubs.acs.org/doi/abs/10.1021/jz501929u

72) J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke "Design of Tunable Multicomponent Polymers as Modular Vehicles to Solubilize Highly Lipophilic Drugs," Macromolecules 2014, 47, 6554–6565. DOI: http://pubs.acs.org/doi/abs/10.1021/ma501839s

71) M. Nasiri, A. Bertrand, T. M. Reineke, M. A. Hillmyer "Polymeric nanocylinders by combining block copolymer self-assembly and nanoskiving," ACS Appl. Mater. Interfaces 2014, 6, 16283–16288. DOI: http://pubs.acs.org/doi/abs/10.1021/am504486r

70) D. Sprouse, T. M. Reineke "Investigating the Effects of Block versus Statistical Glycopolycations Containing Primary and Tertiary Amines for Plasmid DNA Delivery," Biomacromolecules 2014, 15, 2616–2628. DOI: http://pubs.acs.org/doi/abs/10.1021/bm5004527

69) S. Tale, L. Yin, T. M. Reineke "Trehalose-functionalized block copolymers form serum-stable micelles," Polym. Chem. 2014, 5, 5160-5167. DOI: http://pubs.rsc.org/en/content/articlelanding/2014/py/c4py00399c#!divAbstract

68) Y. Wu, M. Wang, D. Sprouse, A. E. Smith, T. M. Reineke "Glucose-Containing Diblock Polycations Exhibit Molecular Weight, Charge, and Cell-Type Dependence for pDNA Delivery," Biomacromolecules 2014, 15, 1716–1726. DOI: http://pubs.acs.org/doi/abs/10.1021/bm5001229

67) S. S. Kelkar, L. Xue, S. R. Richard, T. M. Reineke "Lanthanide-Containing Polycations for Monitoring Polyplex Dynamics via Lanthanide Resonance Energy Transfer," Biomacromolecules 2013, 15, 1612–1624. DOI: http://pubs.acs.org/doi/abs/10.1021/bm401870z

66) J. J. Gallagher, M. A. Hillmyer, T. M. Reineke "Degradable Thermosets from Sugar-Derived Dilactones," Macromolecules 2014, 47, 498–505. DOI: http://pubs.acs.org/doi/abs/10.1021/ma401904x

65) M. C. Dalsin, S. Tale, T. M. Reineke "Solution-State Polymer Assemblies Influence BCS Class II Drug Dissolution and Supersaturation Maintenance," Biomacromolecules 2014, 15, 500–511. DOI: http://pubs.acs.org/doi/abs/10.1021/bm401431t

64) X. Wang, S. S. Kelkar, A. G. Hudson, R. B. Moore, T. M. Reineke, L. A. Madsen "Quantitation of Complexed versus Free Polymers in Interpolyelectrolyte Polyplex Formulations," ACS Macro Lett. 2013, 2, 1038–1041. DOI: http://pubs.acs.org/doi/abs/10.1021/mz400500q

63) P. A. Burke, S. H. Pun, T. M. Reineke "Advancing Polymeric Delivery Systems Amidst a Nucleic Acid Therapy Renaissance," ACS Macro Lett. 2013, 2, 928–934. DOI: http://pubs.acs.org/doi/abs/10.1021/mz400418j

62) A. Sizovs, L. Xue, Z. Tolstyka, N. P. Ingle, Y. Wu, M. Cortez, T. M. Reineke "Poly(trehalose): Sugar-Coated Nanocomplexes Promote Stabilization and Effective Polyplex-Mediated siRNA Delivery," J. Am. Chem. Soc. 2013, 135, 15417–15424. DOI: http://pubs.acs.org/doi/abs/10.1021/ja404941p

61) L. Xue, N. P. Ingle, T. M. Reineke "Highlighting the Role of Polymer Length, Carbohydrate Size, and Nucleic Acid Type in Potency of Glycopolycation Agents for pDNA and siRNA Delivery," Biomacromolecules 2013, 14, 3903–3915. DOI: http://pubs.acs.org/doi/abs/10.1021/bm401026n

60) N. P. Ingle, L. Xue, T. M. Reineke "Spatio-Temporal Cellular Imaging of Polymer-pDNA Nanocomplexes Affords In Situ Morphology and Trafficking Trends," Mol. Pharmaceutics 2013, 10, 4120–4135. DOI: http://pubs.acs.org/doi/abs/10.1021/mp400115y

59) J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke "Precise Compositional Control and Systematic Preparation of Multimonomeric Statistical Copolymers," ACS Macro Lett. 2013, 2, 770-774. DOI: http://pubs.acs.org/doi/abs/10.1021/mz4003112

58) H. Li, M. A. Cortez, H. R. Phillips, Y. Wu, T. M. Reineke "Poly(2-deoxy-2-methacrylamidoglycopyranose)-b-Poly(methacrylate amine)s: Optimization of Diblock Glycopolycations for Nucleic Acid Delivery," ACS Macro Lett. 2013, 2, 230–235. DOI: http://pubs.acs.org/doi/abs/10.1021/mz300660t

57) K. M. Fichter, N. P. Ingle, P. M. McLendon, T. M. Reineke "Polymeric Nucleic Acid Vehicles Exploit Active Interorganelle Traﬃcking Mechanisms," ACS Nano 2013, 7, 347–364. DOI: http://pubs.acs.org/doi/abs/10.1021/nn304218q

56) J. M. Bryson, J. W. Reineke, T. M. Reineke "Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential?," Macromolecules 2012, 45, 8939–8952. DOI: http://pubs.acs.org/doi/abs/10.1021/ma301568u

55) C. Lee, Y. Liu, T. M. Reineke "Glucose-Based Poly(ester amines): Synthesis, Degradation, and Biological Delivery," ACS Macro Lett. 2012, 1, 1388–1392. DOI: http://pubs.acs.org/doi/abs/10.1021/mz300505t

54) K. Anderson, A. Sizovs, M. Cortez, C. Waldron, D. M. Haddleton, T. M. Reineke "Effects of Trehalose Polycation End-Group Functionalization on Plasmid DNA Uptake and Transfection," Biomacromolecules 2012, 13, 2229-2239. DOI: http://pubs.acs.org/doi/abs/10.1021/bm300471n

53) G. Grandinetti, T. M. Reineke "Exploring the Mechanism of Plasmid DNA Nuclear Internalization with Polymer-Based Vehicles," Mol. Pharmaceutics 2012, 9, 2256-2267. DOI: http://pubs.acs.org/doi/abs/10.1021/mp300142d

52) L. Yin, M. C. Dalsin, A. Sizovs, T. M. Reineke, M. A. Hillmyer "Glucose-Functionalized, Serum-Stable Polymeric Micelles from the Combination of Anionic and RAFT Polymerizations," Macromolecules 2012, 45, 4322-4332. DOI: http://pubs.acs.org/doi/abs/10.1021/ma300218n

51) D. J. Buckwalter, A. Sizovs, N. P. Ingle, T. M. Reineke "MAG versus PEG: Incorporating a Poly(MAG) Layer to Promote Colloidal Stability of Nucleic Acid/“Click Cluster” Complexes," ACS Macro Lett. 2012, 1, 609-613. DOI: http://pubs.acs.org/doi/abs/10.1021/mz300081d

50) G. Grandinetti, A. E. Smith, T. M. Reineke "Membrane and Nuclear Permeabilization by Polymeric pDNA Vehicles: Efficient Method for Gene Delivery or Mechanism of Cytoxicity?," Mol. Pharmaceutics 2012, 9, 523-538. DOI: http://pubs.acs.org/doi/abs/10.1021/mp200368p

49) M. Tranter, Y. Liu, S. He, J. Gulick, X. Ren, J. Robbins, W. K. Jones, T. M. Reineke "In Vivo Delivery of Nucleic Acids via Glycopolymer Vehicles Affords Therapeutic Infarct Size Reduction In Vivo," Mol. Ther. 2012, 20, 601-608. DOI: https://www.sciencedirect.com/science/article/pii/S1525001616305172?via%3Dihub

48) T. M. Reineke, M. E. Davis "Nucleic Acid Delivery via Polymer Vehicles," Polymer Science: A Comprehensive Reference 2012, Publisher: Elsevier, K. Matyjaszewski; M. Moeller, eds. DOI: http://dx.doi.org/10.1016/B978-0-444-53349-4.00239-9

47) K. Kizjakina, J. M. Bryson, G. Grandinetti, T. M. Reineke "Cationic Glycopolymers for the Delivery of pDNA to Human Dermal Fibroblasts and Rat Mesenchymal Stem Cells," Biomaterials 2012, 33, 1851-1862. DOI: http://www.sciencedirect.com/science/article/pii/S014296121101235X

46) D. Bryson, W. Zhang, P. McLendon, T. M. Reineke, W. Santos "Toward Targeting RNA Structure: Branched Peptides as Cell-Permeable Ligands to TAR RNA," ACS Chem. Biol. 2012, 7, 210-217. DOI: http://pubs.acs.org/doi/abs/10.1021/cb200181v

45) N. Ingle, B. Malone, T. M. Reineke "Poly(glycoamidoamine)s: A Broad Class of Carbohydrate-Containing Polycations for Nucleic Acid Delivery," Trends Biotechnol. 2011, 29, 443-453. DOI: http://www.cell.com/trends/biotechnology/abstract/S0167-7799(11)00078-3?switch=standard

44) S. Kelkar, T. M. Reineke "Theranostics: Combining Imaging and Therapy," Bioconjugate Chem. 2011, 22, 1879-1903. DOI: http://pubs.acs.org/doi/abs/10.1021/bc200151q

43) G. Grandinetti, N. P. Ingle, T. M. Reineke "Interaction of Poly(ethylenimine)–DNA Polyplexes with Mitochondria: Implications for a Mechanism of Cytotoxicity," Mol. Pharmaceutics 2011, 8, 1709-1719. DOI: http://pubs.acs.org/doi/abs/10.1021/mp200078n

42) A. E. Smith, A. Sizovs, G. Grandinetti, L. Xue, T. M. Reineke "Diblock Glycopolymers Promote Colloidal Stability of Polyplexes and Effective pDNA and siRNA Delivery under Physiological Salt and Serum Conditions," Biomacromolecules 2011, 12, 3015–3022. DOI: http://pubs.acs.org/doi/abs/10.1021/bm200643c

41) V. Taori, H. Lu, T. M. Reineke "Structure-Activity Examination of Poly(glycoamidoamine)s: Glycopolycations Containing Guanidine Units for Nucleic Acid Delivery," Biomacromolecules 2011, 12, 2055-2063. DOI: http://pubs.acs.org/doi/abs/10.1021/bm101537f

40) P. M. McLendon, D. J. Buckwalter, E. M. Davis, T. M. Reineke "Interaction of Poly(glycoamidoamine) DNA Delivery Vehicles with Cell-Surface Glycosaminoglycans Leads to Polyplex Internalization in a Manner Not Solely Dependent on Charge," Mol. Pharmaceutics 2010, 7, 1757-1768. DOI: http://pubs.acs.org/doi/abs/10.1021/mp100135n

39) P. M. McLendon, K. Fichter, T. M. Reineke "Poly(glycoamidoamine) Vehicles Promote pDNA Uptake Through Multiple Routes and Efficient Gene Expression via Caveolae-Mediated Endocytosis," Mol. Pharmaceutics 2010, 7, 738-750. DOI: http://pubs.acs.org/doi/abs/10.1021/mp900282e

38) A. Sizovs, P. M. McLendon, S. Srinivasachari, T. M. Reineke "Carbohydrate Polymers for Nonviral Nucleic Acid Delivery," Top. Curr. Chem. 2010, 296, 131-190. DOI: http://link.springer.com/chapter/10.1007%2F128_2010_68?LI=true

37) C. -C. Lee, G. Grandinetti, P. M. McLendon, T. M. Reineke "A Polycation Scaffold Presenting Tunable “Click” site: Conjugation to Carbohydrate Ligands and Examination of Hepatocyte-Targeted pDNA Delivery," Macromol. Biosci. 2010, 10, 585-598. DOI: http://onlinelibrary.wiley.com/doi/10.1002/mabi.200900431/abstract

36) Y. Liu and T. M. Reineke "Degradation of Poly(glycoamidoamine) DNA Delivery Vehicles: Polyamide Hydrolysis at Physiological Conditions Promotes DNA Release," Biomacromolecules 2010, 11, 316-325. DOI: http://pubs.acs.org/doi/abs/10.1021/bm9008233

35) L. E. Prevette, M. Lynch, T. M. Reineke "Amide Spacing Influences pDNA Binding of Poly(amidoamine)s," Biomacromolecules 2010, 11, 326-332. DOI: http://pubs.acs.org/doi/abs/10.1021/bm900824g

34) J. M. Bryson, K. M. Fichter, W.-J. Chu, J.-H. Lee, J. Li, P. M. McLendon, L. A. Madsen, T. M. Reineke "Polymer Beacons for Luminescence and Magnetic Resonance Imaging of DNA Delivery," Proc. Nat. Acad. Sci. USA 2009, 106, 16913-16918. DOI: http://www.pnas.org/content/106/40/16913.abstract

33) S. Srinivasachari, T. M. Reineke "Versatile Supramolecular pDNA Vehicles via “Click Polymerization” of β-cyclodextrin with Oligoethyleneamines," Biomaterials 2009, 30, 928-938. DOI: http://www.sciencedirect.com/science/article/pii/S0142961208007667

32) V. Taori, Y. Liu, T. M. Reineke "DNA delivery in vitro via surface release from multilayer assemblies with poly(glycoamidoamine)s," Acta Biomater. 2009, 5, 925-933. DOI: http://www.sciencedirect.com/science/article/pii/S1742706109000038

31) J. Bryson, W.–J. Chu, J.–H. Lee, T. M. Reineke "A β-Cyclodextrin “Click Cluster” Decorated with Seven Paramagnetic Chelates Containing Two Water Exchange Sites," Bioconjugate Chem. 2008, 19, 1505-1509. DOI: http://pubs.acs.org/doi/abs/10.1021/bc800200q

30) L. E. Prevette, K. Kizjakina, M. Lynch, T. M. Reineke "Correlation of Amine Number and pDNA Binding Mechanism for Trehalose-Based Polycations," Langmuir 2008, 24, 8090-8101. DOI: http://pubs.acs.org/doi/abs/10.1021/la800120q

29) S. Srinivasachari, K. M. Fichter, T. M. Reineke "Polycationic β-Cyclodextrin “Click Clusters”: Monodisperse and Versatile Scaffolds for Nucleic Acid Delivery," J. Am. Chem. Soc. 2008, 130, 4618–4627. DOI: http://pubs.acs.org/doi/abs/10.1021/ja074597v

28) C. Gulgas, T. M. Reineke "Macrocyclic Eu3+ Chelates Show Selective Luminescent Responses to Anions," Inorg. Chem. 2008, 47, 1548-1559. DOI: http://pubs.acs.org/doi/abs/10.1021/ic701916z

27) R. Lucas, M. Benjamin, T. M. Reineke "Comparison of a Tartaric Acid Derived Polymeric MRI Contrast Agent to a Small Molecule Model Chelate," Bioconjugate Chem. 2008, 19, 24-27. DOI: http://pubs.acs.org/doi/abs/10.1021/bc700375m?journalCode=bcches

26) K. M. Fichter, L. Zhang, K. L. Kiick, T. M. Reineke "Peptide-Functionalized Poly(ethylene glycol) Star Polymers: DNA Delivery Vehicles with Multivalent Molecular Architecture," Bioconjugate Chem. 2008, 19, 76-88. DOI: http://pubs.acs.org/doi/abs/10.1021/bc0701141

25) C.–C. Lee, Y. Liu, T. M. Reineke "General Structure–Activity Relationship for Poly(glycoamidoamine)s: The Effect of Amine Density on Cytotoxicity and DNA Delivery Efficiency," Bioconjugate Chem. 2008, 19, 428-440. DOI: http://pubs.acs.org/doi/abs/10.1021/bc7001659

24) L. Prevette, T. Krodger, T. M. Reineke, M. L. Lynch "Deciphering the Role of Hydrogen Bonding In Enhancing DNA-Polycation Interactions," Langmuir 2007, 23, 9773-9784. DOI: http://pubs.acs.org/doi/abs/10.1021/la7009995

23) S. Srinivasachari, Y. Liu, L. E. Prevette, T. M. Reineke "Effects of trehalose click polymer length on pDNA complex stability and delivery efficacy," Biomaterials 2007, 28, 2885-2898. DOI: http://www.sciencedirect.com/science/article/pii/S0142961207001238

22) Y. Liu, T. M. Reineke "Poly(glycoamidoamine)s for Gene Delivery. Structural Effects on Cellular Internalization, Buffering Capacity, and Gene Expression," Bioconjugate Chem. 2007, 18, 19-30. DOI: http://pubs.acs.org/doi/abs/10.1021/bc060029d

21) Y. Liu, L. Wenning, M. Lynch, T. M. Reineke "Gene Delivery with Novel Poly(l-tartaramidoamine)s," Polymeric Drug Delivery Volume I - Particulate Drug Carriers 2006, Svenson, S. (Ed.), ACS Symposium Series, Vol. 923, American Chemical Society, Washington, DC, 217-227. DOI: http://pubs.acs.org/doi/abs/10.1021/bk-2006-0923.ch015

20) Y. Liu, T. M. Reineke "Poly(glycoamidoamine)s for Gene Delivery: Stability of Polyplexes and Efficacy with Cardiomyoblast Cells," Bioconjugate Chem. 2006, 17, 101-108. DOI: http://pubs.acs.org/doi/abs/10.1021/bc050275%2B

19) S. Srinivasachari, Y. Liu, G. Zhang, L. Prevette, T. M. Reineke "Trehalose Click Polymers Inhibit Nanoparticle Aggregation and Promote pDNA Delivery in Serum," J. Am. Chem. Soc. 2006, 128, 8176-8184. DOI: http://pubs.acs.org/doi/abs/10.1021/ja0585580

18) T. M. Reineke "Poly(glycoamidoamine)s: Cationic Glycopolymers for DNA Delivery," J. Polym. Sci. A Polym. Chem. 2006, 44, 6895-6908. DOI: http://onlinelibrary.wiley.com/doi/10.1002/pola.21697/abstract

17) Y. Liu, T. M. Reineke "Hydroxyl Stereochemistry and Amine Number within Poly(glycoamidoamine)s Affect Intracellular DNA Delivery," J. Am. Chem. Soc. 2005, 127, 3004-3015. DOI: http://pubs.acs.org/doi/abs/10.1021/ja0436446

16) T. M. Reineke, M. W. Grinstaff "Designer Materials for Nucleic Acid Delivery," MRS Bull. 2005, 30, 635-639. DOI: https://www.cambridge.org/core/journals/mrs-bulletin/article/designer-materials-for-nucleic-acid-delivery/632AECAE04F5C65A6A31EA50A66C8697

15) C. Gulgas, T. M. Reineke "Synthesis, Characterization, and Luminescence Properties of a New Series of Eu3+ – Containing Macrocycles," Inorg. Chem. 2005, 44, 9829-9836. DOI: http://pubs.acs.org/doi/abs/10.1021/ic051324x

14) M. E. Davis, S. H. Pun, N. C. Bellocq, T. M. Reineke, S. R. Popielarski, S. Mishra, J. D. Heidel "Self-Assembling Nucleic Acid Delivery Vehicles via Linear, Water-Soluble, Cyclodextrin-Containing Polymers," Curr. Med. Chem. 2004, 11, 179-197. DOI: http://www.eurekaselect.com/61984/article

13) Y. Liu, L. Wenning, M. Lynch, T. M. Reineke "New Poly(D-glucaramidoamine)s Induce DNA Nanoparticle Formation and Efficient Gene Delivery into Mammalian Cells," J. Am. Chem. Soc. 2004, 126, 7422-7423. DOI: http://pubs.acs.org/doi/abs/10.1021/ja049831l

12) T. M. Reineke, M. E. Davis "Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 2. Charge Center Type," Bioconjugate Chem. 2003, 14, 255-261. DOI: http://pubs.acs.org/doi/abs/10.1021/bc025593c

11) T. M. Reineke, M. E. Davis "Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 1. Carbohydrate Size and Its Distance from Charge Centers," Bioconjugate Chem. 2003, 14, 247-254. DOI: http://pubs.acs.org/doi/abs/10.1021/bc025592k

10) T. M. Reineke, M. E. Davis "The Effects of Charge Separation in Quaternary, Ammonium, DABCO-Containing Polymers on In Vitro Toxicity and Gene Delivery," Mat. Res. Soc. Symp. Proc. 2002, 724, N10.2.1-N10.2.6. DOI: http://dx.doi.org/10.1557/PROC-724-N10.2

9) J. Kim, B. Chen, T. M. Reineke, H. Li, M. Eddaoudi, D. B. Moler, M. O’Keeffe, O. M. Yaghi "Assembly of Metal-Organic Frameworks from Large Organic and Inorganic Secondary Building Units: New Examples and Simplifying Principles for Complex Structures," J. Am. Chem. Soc. 2001, 123, 8239-8247. DOI: http://pubs.acs.org/doi/abs/10.1021/ja010825o

8) M. Eddaoudi, D. B. Moler, H. Li, T. M. Reineke, B. L. Chen, M. O’Keeffe, O. M. Yaghi "Modular Chemistry: Secondary Building Units as a Basis for the Design of Highly Porous and Robust Metal-Organic Frameworks," Acc. Chem. Res. 2001, 34, 319-330. DOI: http://pubs.acs.org/doi/abs/10.1021/ar000034b

7) B. L. Chen, M. Eddaoudi, T. M. Reineke, J. W. Kampf, M. O’Keeffe, O. M. Yaghi "Cu2(ATC)·6H2O: Design of Open Metal Sites in Porous Metal−Organic Crystals (ATC: 1,3,5,7-Adamantane Tetracarboxylate)," J. Am. Chem. Soc. 2000, 122, 11559-11560. DOI: http://pubs.acs.org/doi/abs/10.1021/ja003159k

6) T. M. Reineke, M. Eddaoudi, D. Moler, M. O’Keeffe, O. M. Yaghi "Large Free Volume in Maximally Interpenetrating Networks: The Role of Secondary Building Units Exemplified by Tb2(ADB)3[(CH3)2SO]4•16[(CH3)2SO]," J. Am. Chem. Soc. 2000, 122, 4843-4844. DOI: http://pubs.acs.org/doi/abs/10.1021/ja000363z

5) M. O’Keeffe, M. Eddaoudi, H. Li, T. Reineke, O. M. Yaghi "Frameworks for Extended Solids: Geometrical Design Principals," J. Solid State Chem. 2000, 152, 3-20. DOI: http://www.sciencedirect.com/science/article/pii/S0022459600987231

4) T. M. Reineke, M. Eddaoudi, M. O’Keeffe, O. M. Yaghi "A Microporous Lanthanide-Organic Framework”," Angew. Chem. 1999, 38, 2590-2594. DOI: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-3773(19990903)38:17%3C2590::AID-ANIE2590%3E3.0.CO;2-H/abstract

3) T. M. Reineke, M. Eddaoudi, M. Fehr, D. Kelley, O. M. Yaghi "From Condensed Lanthanide Coordination Solids to Microporous Frameworks Having Accessible Metal Sites," J. Am. Chem. Soc. 1999, 121,1651-1657. DOI: http://pubs.acs.org/doi/abs/10.1021/ja983577d

2) M. Eddaoudi, H. Li, T. Reineke, M. Fehr, D. Kelley, T. L. Groy, O. M. Yaghi "Design and Synthesis of Metal-Carboxylate Frameworks with Permanent Microporosity," Top. Catal. 1999, 9, 105-111. DOI: http://rd.springer.com/article/10.1023/A%3A1019110622091

1) C. L. Muller, J. R. Bever, M. A. Dordel, M. M. Kitabwalla, T. M. Reineke, J. B. Sausker, T. R. Seehafer, Y. Li, J. P. Jasinski "Regiochemistry of Intramolecular Photocycloaddition of 1,3-Dioxin-4-ones Tethered Through the Ketal Carbon," Tetrahedron Lett. 1997, 38, 8663-8666. DOI: http://www.sciencedirect.com/science/article/pii/S0040403997103811

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